Signs of Edema include: ankle & leg swelling, changes in skin pigmentation, pain and discomfort particularly in the calf and/or ankle. Swelling and leg edema can be caused by an abnormal buildup of fluid in the soft tissues of the leg. Edema is multifactorial and can be caused by lymphatic dysfunction and/or a more progressive stage of venous reflux disease. Increased venous hypertension forces fluid to diffuse into the tissues beneath the skin. Edema can be part of the spectrum of symptoms that occur in a patient with venous disease. Leg swelling can occur in any part of the legs, including the feet, ankles, calves or thighs. Ankle or foot swelling caused by venous reflux and components of lymphatic dysfunction can be reduced with a vein treatment, such as RF ablation or ultrasound guided sclerotherapy.